Heterocyclic compounds being highly reactive found to possess various pharmacological activities. Among the various heterocyclic rings pyrimidines and pyrazolines play a vital role in biological processes as found in natural and also synthetic lead molecules. In the present study new pyrimidines and pyrazolines were synthesized via a,�Ÿ-unsaturated carbonyl compounds (Chalcones). The synthesized compounds were characterized by means of their IR, 1H NMR and Mass spectral data. The compounds were evaluated for anticonvulsant activity by maximal electro shock method and the compounds were proven to possess significant activity. The synthesized compounds were studied for druglikeliness by calculating druglikeliness descriptors. A theoretical approach is also made to these synthesized molecules to predict adverse effects using OSIRIS software which helps to develop lead molecules.
Loading....